Browsing by Author "Ruiz-Patiño, A."

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    Characteristics and outcomes of thymomas in Latin America: Results from over 10 years of experience (CLICaP-LATimus)
    (Thorac Cancer, 2021) Martín, Claudio; Enrico, Diego; Mas, Luis; Patane, Ana Karina; Arrieta, Oscar; Soria, Tannia; Cardona, Andres F.; Ruiz-Patiño, A.; Ruiz, Rossana; Rioja, Patricia; Lozano, Sophia; Zatarain-Barrón Zyanya Lucia; Barrón, Feliciano; Puparelli, Carmen; Tsou Florencia; Corassa, Marcelo P.; Freitas, Helano C.; Cordeiro de Lima, Vladmir Cláudio; Rojas, Leonardo; Ordóñez-Reyes, Camila; Corrales, Luis; Sotelo, Carolina; Rodríguez, July; Ricaurte, Luisa; Ávila, Jenny; Archila, Pilar; Rosell, Rafael; Cuello, Mauricio; Remon, Jordi
    Background: Thymomas are a group of rare neoplasms of the anterior mediastinum. The objective of this study was to describe the demographics, clinical characteristics and treatment approaches in Latin America. Methods: This was a retrospective multicenter cohort study including patients with histologically proven thymomas diagnosed between 1997 and 2018. Demographics, clinicopathological characteristics and therapeutic outcomes were collected locally and analyzed in a centralized manner. Results: A total of 135 patients were included. Median age at diagnosis was 53 years old (19-84), 53.3% (n = 72) of patients were female and 87.4% had an ECOG performance score ranging from 0-1. A total of 47 patients (34.8%) had metastatic disease at diagnosis. Concurrent myasthenia gravis occurred in 21.5% of patients. Surgery was performed in 74 patients (54.8%), comprising 27 (20%) tumorectomies and 47 (34.8%) thymectomies. According to the Masaoka-Koga system, overall survival (OS) at five-years was 73.4%, 63.8% and 51%, at stages I-II, III-IVA and IVB, respectively (p = 0.005). Furthermore, patients with low lactate dehydrogenase (LDH) (≤373 IU/L) at baseline and myasthenia gravis concurrence showed significantly better OS (p = 0.001 and p = 0.008, respectively). In multivariate analysis, high LDH levels (HR 2.8 [95% confidence interval [CI]: 1.1-7.8]; p = 0.036) at baseline and not performing a surgical resection (HR 4.1 [95% CI: 1.3-12.7]; p = 0.016) were significantly associated with increased risk of death. Conclusions: Our data provides the largest insight into the clinical characteristics and outcomes of patients with thymomas in Latin America. Survival in patients with thymomas continues to be very favorable, especially when subjected to adequate local control. Keywords: Latin America; cohort studies; medical oncology; thymoma.
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    Real World Characterization and Treatment of Patients with Thymic Carcinoma: Lessons from a Latin-American Study (CLICaP-LATimus)
    (J Thorac Oncol, 2019) Mas, L.; Patané, A.; Arrieta, O.G.; Soria, Tannia; Cardona, A.F.; Martin, C.; Ruiz-Patiño, A.; Rojas L.L.; Ruiz, R.; Rioja, P.; Lozano, S.; Zatarain Barrón, Z.L.; Corassa, M.; Freitas, H.; Cordeiro de Lima, V.; Corrales, L.; Sotelo, C.; Rodriguez, J.; Ricaurte, L.; Ávila, J.; Bravo, M.; Mayorga, D.; Archila, P.; Otero, J.; Carranza, H.; Vargas, C.; Rosell, R.; Remon, J.
    Background Thymic carcinoma is a rare tumor that represents a clinical challenge, especially in resource limited settings. The objective of the present study was to characterize patients who presented this disease in Latin-America. Method From 2014 until 2018, a multinational Latin-American cooperative retrospective cohort study was performed. Patients with histologically confirmed thymic carcinoma were included. Clinical, pathological and treatment variables were collected across 7 participating nations. Result A total of 31 patients were included. Median age at diagnosis was 58 years old (34-69), 48% (n=15) of individuals were women with all but 2 patients (6.5%) achieving an ECOG performance score <2. All patients debuted with Stage IV disease; 24 patients (66%, [95%CI 62-92%]) as stage IVa and 7 as stage IVb (33%, [95%CI 7-37%]) with a median LDH level of 396.5 U/L (153-1529 U/L) and a median of 2 metastatic sites. 13 (41.9%, [95%CI 25-59%]) patients received preoperatory treatment consisting of chemotherapy (n=8, 42%) and chemoradiotherapy (n=5, 16%). Among these patients only 4 (12.9%) were subjected to surgery, two of which underwent a tumorectomy and 2 a thymectomy. 28 (90%, [95%CI 79.9-100%]) received palliative chemotherapy either with sunitinib (n=7, 25%) or cytotoxic agents. Median overall survival (OS) was reached at 20.2 months (95%CI 19-NA months). Patients who received preoperative treatment had a significantly prolonged OS (17.6 vs 26 months, HR 2.93 [95%CI 1.04-8.27 months], p = 0.03). Conclusion Thymic carcinoma constitutes an aggressive disease that is often diagnosed in advanced stages. These results suggest that multimodal treatment can be beneficial even in locally advanced cases. Larger clinical trial validating these conclusions are warranted. Keywords Real world data, Latin America, thymic sarcoma
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    Survival of Thymoma Is Extensive in Latin-American Patients: Results from over 10 Years of Experience (CLICaP-LATimus)
    (J Thorac Oncol, 2019) Mas, L.; Patane A.K.; Arrieta, O.; Soria, Tannia.; Cardona, A.F.; Martín, C.; Ruiz-Patiño, A.; Ruiz, R.; Rioja, P.; Lozano, S.; Zatarain Barron, L.; Barrón, F.; Corassa, M.; Freitas, H.; Cordeiro De Lima, V.C.; Corrales-Rodriguez, L.; Sotelo, C.; Rodríguez, J.; Ricaurte, L.; Ávila, J.; Mayorga, D.; Bravo, M.; Archila, P.; Otero, J.; Carranza, H.; Vargas, C.; Rosell, R.; Remon, J.
    Background Thymomas are a group of rare neoplasm of the anterior mediastinum. Due to their low incidence, large cooperative studies are required to evaluate outcomes. The objective of this study is to present the results and experience in treatment of this pathology in Latin-America. Method A retrospective multicenter cohort study was conducted by The Latin-American Consortium for the Investigation of Lung Cancer (CLICaP). Patients with histologically proven thymomas between 1997 and 2018 were included in the analysis. Variables including clinical, pathological and therapeutic outcomes were registered in a centralized manner. Results A total of 105 patients were included. Median age at diagnosis was 54 years old (20-84), and with 60% (n = 38) of the included patients were female. Only 11% (n=7) of the patients had an ECOG performance score >1. Twenty-four patients (22.9%, 95%CI 14.8-30.9) presented with pulmonary or distant metastatic involvement with a median of 2 metastatic sites. Furthermore, 21.9 % of patients (n=23, 95%CI 13.9-29.8%) concurrently presented myasthenia gravis. Surgery was performed in 55 patients (52.3%, 95%CI 42.8 – 61.9%), comprising of 15 tumorectomies, 37 thymectomies and 5 biopsies achieving an R0 resection rate of 78% (95%CI 67.3-89.1%). Adjuvant treatment in the form of either chemotherapy, radiotherapy or both was offered to 3(5%), 7(12.7%) and 5(9%) patients, respectively. Disease progression was documented in 10 cases (9%, 95%CI3.9-15.1%) of which 6 (60%) were locoregional, 1 (10%) distant progression and 3 (30%) both locoregional and distant. Median overall survival (OS) was estimated at around 139.5 months (95%CI 86.1-NA). Cox regression indicated that OS was significantly improved by resection (139.5 vs 25.7 months, HR 4.17 [95%CI 12.6-17.8 months]). Conclusion Survival in patients with thymomas continues to be very favorable, especially in patients who receive adequate local control. The benefit of adjuvant treatment in this setting remains unclear. Keywords Local control, Adjuvant therapy, Survival