Publication: Lung cancer: EGFR-ALK mutation in the high lands
Date
2018
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Journal of Clinical Oncology
Abstract
Background: It has been shown that oxygen is a driver of damage forming free radicals, at higher areas of altitude the risk of developing lung cancer decreases, the primary endpoint was to identify the incidence of EGFR-ALK mutation in the high lands and as a secondary endpoint was to determine the relationship among a pulmonary lobe location, EGFR-ALK mutation and tobacco use. Methods: All patients with lung cancer living at an altitude between 2500( meters above sea level) masl to 3000 masl treated at the Hospital Solon Espinosa Ayala "Quito-Ecuador" between the year 2010 and 2015. The characteristics of the patients included in this study were: living in the high lands for more than 30 years, to have a EGFR and ALK mutation reported. All this data were collected from the electronic medical records. A descriptive analysis of the EGFR and ALK mutation were performed in our city, the Fisher test was used to compare the mutation of EGFR with the location of a pulmonary lobe in a physiological way, whether the tumor is located in superior or inferior lobe and also with tobacco use. Results: Among 191 individuals, 154 individuals were excluded as the did not meet the inclusion criteria, with a total of 37 individuals, with an EGFR mutation in 48.6% (18/37) and an ALK mutation in 3% ( 1/37) of patients. Although 50% of the EGFR mutations belonged to a superior lobe location, this was not significant statistically OR = 2.25 IC 95% (0.61 - 8.18); p = 0.15, the EGFR mutation was not affected by tobacco consumption in our data, presented in the non-smoker individuals OR = 1.47 IC 95% (0.80 - 2.71); p = 0.21. Conclusions: The incidence of EGFR mutation is high, practically presenting a 1: 1 ratio, while the incidence of ALK mutation was very low; Although the EGFR mutation was higher in the upper lobe tumor location, it was not significant, and it was a finding that tobacco consumption was not related to the EGFR mutation present.
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Citation
Villacres LD, Villarroel N, Moreno P, Carrasco EA, Castillo J, Munoz MJ, ; Soria T, et al. Lung cancer: EGFR-ALK mutation in the high lands. Journal of Clinical Oncology; 2018.