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Survival of Thymoma Is Extensive in Latin-American Patients: Results from over 10 Years of Experience (CLICaP-LATimus)

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dc.contributor.authorMas, L.
dc.contributor.authorPatane A.K.
dc.contributor.authorArrieta, O.
dc.contributor.authorSoria, Tannia.
dc.contributor.authorCardona, A.F.
dc.contributor.authorMartín, C.
dc.contributor.authorRuiz-Patiño, A.
dc.contributor.authorRuiz, R.
dc.contributor.authorRioja, P.
dc.contributor.authorLozano, S.
dc.contributor.authorZatarain Barron, L.
dc.contributor.authorBarrón, F.
dc.contributor.authorCorassa, M.
dc.contributor.authorFreitas, H.
dc.contributor.authorCordeiro De Lima, V.C.
dc.contributor.authorCorrales-Rodriguez, L.
dc.contributor.authorSotelo, C.
dc.contributor.authorRodríguez, J.
dc.contributor.authorRicaurte, L.
dc.contributor.authorÁvila, J.
dc.contributor.authorMayorga, D.
dc.contributor.authorBravo, M.
dc.contributor.authorArchila, P.
dc.contributor.authorOtero, J.
dc.contributor.authorCarranza, H.
dc.contributor.authorVargas, C.
dc.contributor.authorRosell, R.
dc.contributor.authorRemon, J.
dc.date.accessioned2023-06-28T18:19:10Z
dc.date.available2023-06-28T18:19:10Z
dc.date.issued2019
dc.description.abstractBackground Thymomas are a group of rare neoplasm of the anterior mediastinum. Due to their low incidence, large cooperative studies are required to evaluate outcomes. The objective of this study is to present the results and experience in treatment of this pathology in Latin-America. Method A retrospective multicenter cohort study was conducted by The Latin-American Consortium for the Investigation of Lung Cancer (CLICaP). Patients with histologically proven thymomas between 1997 and 2018 were included in the analysis. Variables including clinical, pathological and therapeutic outcomes were registered in a centralized manner. Results A total of 105 patients were included. Median age at diagnosis was 54 years old (20-84), and with 60% (n = 38) of the included patients were female. Only 11% (n=7) of the patients had an ECOG performance score >1. Twenty-four patients (22.9%, 95%CI 14.8-30.9) presented with pulmonary or distant metastatic involvement with a median of 2 metastatic sites. Furthermore, 21.9 % of patients (n=23, 95%CI 13.9-29.8%) concurrently presented myasthenia gravis. Surgery was performed in 55 patients (52.3%, 95%CI 42.8 – 61.9%), comprising of 15 tumorectomies, 37 thymectomies and 5 biopsies achieving an R0 resection rate of 78% (95%CI 67.3-89.1%). Adjuvant treatment in the form of either chemotherapy, radiotherapy or both was offered to 3(5%), 7(12.7%) and 5(9%) patients, respectively. Disease progression was documented in 10 cases (9%, 95%CI3.9-15.1%) of which 6 (60%) were locoregional, 1 (10%) distant progression and 3 (30%) both locoregional and distant. Median overall survival (OS) was estimated at around 139.5 months (95%CI 86.1-NA). Cox regression indicated that OS was significantly improved by resection (139.5 vs 25.7 months, HR 4.17 [95%CI 12.6-17.8 months]). Conclusion Survival in patients with thymomas continues to be very favorable, especially in patients who receive adequate local control. The benefit of adjuvant treatment in this setting remains unclear. Keywords Local control, Adjuvant therapy, Survival
dc.identifier.citationMas L, Patane AK, Arrieta O, Soria T, Cardona AF, Martín C, et al. P1. 10 Survival of Thymoma Is Extensive in Latin-American Patients: Results from over 10 Years of Experience (CLICaP-LATimus). J Thorac Oncol. 2019;14(11):S1177–8
dc.identifier.urihttp://biblioteca.solcaquito.org.ec:9997/handle/123456789/429
dc.language.isoen
dc.publisherJ Thorac Oncol
dc.titleSurvival of Thymoma Is Extensive in Latin-American Patients: Results from over 10 Years of Experience (CLICaP-LATimus)
dc.typeArticle
dspace.entity.typePublication
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