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Personalizing Precision Oncology Clinical Trials in Latin America: An Expert Panel on Challenges and Opportunities

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dc.contributor.authorArai, Roberto Jun
dc.contributor.authorGuindalini, Rodrigo Santa Cruz
dc.contributor.authorLlera, Andrea Sabina
dc.contributor.authorO'Connor, Juan Manoel
dc.contributor.authorMuller, Bettina
dc.contributor.authorLema, Mauricio
dc.contributor.authorFreitas, Helano C.
dc.contributor.authorSoria, Tannia
dc.contributor.authorDelgado, Lucía
dc.contributor.authorLandaverde, Denis
dc.contributor.authorMontenegro, Paola
dc.contributor.authorRiechelmann, Rachel P.
dc.date.accessioned2023-06-27T13:00:13Z
dc.date.available2023-06-27T13:00:13Z
dc.date.issued2019
dc.description.abstractAbstract The participation of patients in precision oncology trials needs to fulfill molecular-based selection criteria. This strongly limits accrual, and as a consequence, screening successes have decreased, costs have increased, and fewer subjects are enrolled. To achieve narrowed targets, studies have been forced to be multicenter and multinational to reach a larger pool of candidates. However, this globalization faces many challenges, as, for example, in the case of precision oncology trials. These trials have a complex structure that is dependent upon a high-tech infrastructure and knowledge in a dynamic environment. Given the movement of precision clinical cancer research to regions other than Europe and the U.S., it is important to evaluate the feasibility of performing such trials in lower-middle- and low-income countries. Here we critically discuss the advantages of conducting precision oncology clinical trials in Latin America and make suggestions on how to overcome the main challenges involved. IMPLICATIONS FOR PRACTICE: Precision clinical trials in oncology are studies that require candidates to have tumors with specific molecular alterations, which are considered the target for the trial experimental therapy. Because many molecular alterations are rare, fewer patients are enrolled. This has led to trials being forced to be multicenter and multinational, including trials in Latin America. This article discusses the challenges and opportunities to conduct precision oncology trials in Latin America, aiming to help sponsors and investigators to solve complex issues that ultimately lead to more of such trials being run in the region, potentially benefiting more Latin American patients with cancer. Keywords: Cancer; Clinical trials; Global oncology; Precision oncology.
dc.identifier.citationArai RJ, Guindalini RSC, Llera AS, O'Connor JM, Muller B, Lema M, Freitas HC, Soria T, Delgado L, Landaverde D, Montenegro P, Riechelmann RP. Personalizing Precision Oncology Clinical Trials in Latin America: An Expert Panel on Challenges and Opportunities. Oncologist. 2019 Aug;24(8):e709-e719. doi: 10.1634/theoncologist.2018-0318. Epub 2019 Mar 25. PMID: 30910864; PMCID: PMC6693712.
dc.identifier.urihttp://biblioteca.solcaquito.org.ec:9997/handle/123456789/406
dc.language.isoen
dc.publisherThe Oncologist
dc.titlePersonalizing Precision Oncology Clinical Trials in Latin America: An Expert Panel on Challenges and Opportunities
dc.typeArticle
dspace.entity.typePublication
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