DSpace 7

DSpace is the world leading open source repository platform that enables organisations to:

easily ingest documents, audio, video, datasets and their corresponding Dublin Core metadata
open up this content to local and global audiences, thanks to the OAI-PMH interface and Google Scholar optimizations
issue permanent urls and trustworthy identifiers, including optional integrations with handle.net and DataCite DOI

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Now showing 1 - 5 of 8

Recent Submissions

Pirtobrutinib in Richter syndrome: Outcomes from the named patient programme in Italy
(British Society for Haematology and John Wiley & Sons Ltd., 2026) Ferrarini, Isacco; Banegas, Daniela Estefania; Bernardelli, Andrea; Moioli, Alessia; Quaglia, Francesca Maria; Lovato, Ester; Frustaci, Anna Maria; Postorino, Massimiliano; Facchinelli, Davide; Tani, Monica; Cibien, Francesca; Toldo, Chandrakala; Lucchini, Elisa; Marasca, Roberto; Varettoni, Marzia; Rusconi, Chiara; Farina, Lucia; Visentin, Andrea; Moia, Riccardo; Visco, Carlo
Efficacy and safety of systemic morphine for persistent breathlessness in adults with advanced nonmalignant disease: a systematic review and meta-analysis of randomized trials
(Palliative Medicine in Practice, 2026-09) Barrezueta Román, Roxana Valentina; Rosales Cevallos, Alexandra Elizabeth; Palma Sanchez, Ronald Manuel
Background. Morphine is used for persistent breathlessness despite uncertainty about its efficacy and safety in advanced nonmalignant diseases. We evaluated its symptomatic, functional, physiologic, and adverse effects. Methods. We conducted a systematic review of randomized trials comparing systemic morphine with placebo or usual care in adults with persistent breathlessness due to advanced nonmalignant disease. We excluded acute or cancer-related breathlessness and non-systemic administration. PubMed, Embase, Scopus, and Web of Science were searched through July 2026. PRISMA 2020, RoB 2, and GRADE were applied. Random-effects meta-analyses used the Paule–Mandel estimator with Hartung–Knapp adjustment. Results. Of 2,721 records, 15 reports representing 11 independent cohorts and 840 participants were included; five cohorts contributed to six meta-analyses. Compared with placebo, morphine probably results in little to no difference in worst daily-life breathlessness [mean difference (MD), −0.15; 95% confidence interval (CI), −0.63 to 0.34; moderate certainty] and may result in little to no difference in average breathlessness (MD, −0.09; 95% CI, −0.61 to 0.42; low certainty). Evidence for six-minute walk distance and respiratory rate was very uncertain. Changes in oxygen saturation and carbon dioxide tension were small and of low certainty. Several trials reported more adverse events or discontinuations with morphine, but heterogeneity in outcome measurement precluded pooling. Conclusions. Short-term randomized evidence does not support expecting a clinically important benefit of regular oral morphine for daily-life breathlessness. Any therapeutic trial should be individualized, time limited, and closely monitored. Keywords: dyspnea; morphine; analgesics, opioid; palliative care; systematic reviews as topic; randomized controlled trials as topic; meta-analysis as topic
El Cáncer: La Pandemia Silenciosa: Una mirada desde el Registro de Tumores SOLCA Cuenca
(2026) Sociedad de Lucha Contra el Cáncer Solca Cuenca; Registro de Tumores de base poblacional SOLCA CUENCA; Campoverde, Nicolás; Orbe, María José
TNM Supplement A Commentary on Uniform Use
(Springer-Verlag, 1993) Hutter, R. V. P.
Líquidos y electrólitos. Sus alteraciones
(Editorial Médica Panamericana, 1964) Snively, W. D.; Sweeney, M. J.; Hall, William; Lo Presti, Joseph; Kulick, George; Pareira, Norton